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How to Integrate AI Agents with Epic & Cerner: Utilizing FHIR and SMART APIs

How to Build an AI Agent That Integrates with Epic

CapMinds provided a technical guide detailing how to build secure AI agents that integrate with Epic and Cerner EHR systems using FHIR.

December 26, 2025CapMinds

Summary

Healthcare institutions are advancing the adoption of AI agents into Electronic Health Records (EHRs), with integration into major platforms like Epic and Cerner being a key focus. This article explains the concrete integration methods and technical challenges by utilizing standards such as FHIR and SMART-on-FHIR, which these systems support.

Key Players

EpicCernerFHIR

Details

The use of AI agents is advancing in healthcare, focusing on embedding them directly into major EHR vendors like Epic and Cerner (now Oracle Health). These platforms strongly support interoperability standards such as HL7 FHIR, enabling data exchange with third-party applications via REST APIs. Developers utilize FHIR resources (Patient, Observation, etc.) and establish authorization and EHR launch context using the SMART-on-FHIR profile. Both Epic and Cerner provide dedicated developer portals, recommending testing in sandbox environments based on security protocols like OAuth2. Furthermore, when real-time capability is required, HL7 v2 or IHE interfaces must also be considered. AI agent use cases include appointment management (using Appointment resources), patient outreach, and clinical documentation support, all of which are achievable through FHIR APIs.

Technology Note

FHIR(Fast Healthcare Interoperability Resources)は医療データ交換の国際標準。このエントリの関連技術: FHIR

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