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Mirth Connect and FHIR: Powering the Next Generation of Healthcare Data Exchange

Mirth Connect + FHIR: Powering the Next Generation of Healthcare Data Exchange

March 26, 2026Mirth Support

Summary

Mirth Connect functions as an integration engine, enabling real-time, bidirectional healthcare data exchange by integrating with FHIR R4. This bridges established infrastructure using HL7 v2 systems with the modern FHIR API ecosystem, supporting data flow across all care settings.

Details

Mirth Connect is an open-source integration engine that has served as a backbone for healthcare connectivity for over two decades. With FHIR R4 becoming the de facto standard for healthcare API development, Mirth Connect has evolved to meet this demand. It combines FHIR-native connectors with its powerful JavaScript transformation engine to bridge the enormous installed base of HL7 v2 systems with the modern FHIR API ecosystem. Key capabilities include bidirectional FHIR exchange (supporting both server and client modes) and real-time translation of incoming HL7 v2 messages (such as ADT, ORM, ORU) into FHIR R4 resources. Security is enhanced through integration with SMART on FHIR OAuth 2.0 for secure API access. Furthermore, the platform includes built-in validation against US Core, Da Vinci, and CARIN implementation guides to ensure regulatory compliance. The data flow process involves receiving source system data (e.g., HL7 v2 message), parsing and transforming it using JavaScript logic into FHIR R4 resources, validating the resource against a target profile, and finally routing it to a destination FHIR server or API endpoint. This comprehensive architecture ensures that diverse clinical data from EHRs can be processed quickly and standardized for modern consumption.

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